KEGG   Homo sapiens (human): 3293
Entry
3293              CDS       T01001                                 
Symbol
HSD17B3, EDH17B3, SDR12C2
Name
(RefSeq) hydroxysteroid 17-beta dehydrogenase 3
  KO
K10207  testosterone 17beta-dehydrogenase (NADP+) [EC:1.1.1.64]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00140  Steroid hormone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
hsa_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Network
nt06019  Steroid hormone biosynthesis
  Element
N01541  Testosterone biosynthesis
N01802  Dihydrotestosterone biosynthesis
Disease
H00608  46,XY disorder of sex development due to testosterone secretion defect
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    3293 (HSD17B3)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.64  testosterone 17beta-dehydrogenase (NADP+)
     3293 (HSD17B3)
SSDB
Motif
Pfam: adh_short adh_short_C2 KR Sacchrp_dh_NADP ApbA Shikimate_DH DUF3993
Other DBs
NCBI-GeneID: 3293
NCBI-ProteinID: NP_000188
OMIM: 605573
HGNC: 5212
Ensembl: ENSG00000130948
UniProt: P37058 Q6FH62
Position
9:complement(96235306..96302176)
AA seq 310 aa
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
NT seq 933 nt   +upstreamnt  +downstreamnt
atgggggacgtcctggaacagttcttcatcctcacagggctgctggtgtgcctggcctgc
ctggcgaagtgcgtgagattctccagatgtgttttactgaactactggaaagttttgcca
aagtctttcttgcggtcaatgggacagtgggcagtgatcactggagcaggcgatggaatt
gggaaagcgtactcgttcgagctagcaaaacgtggactcaatgttgtccttattagccgg
acgctggaaaaactagaggccattgccacagagatcgagcggactacagggaggagtgtg
aagattatacaagcagattttacaaaagatgacatctacgagcatattaaagaaaaactt
gcaggcttagaaattggaattttagtcaacaatgtcggaatgcttccaaaccttctccca
agccatttcctgaacgcaccggatgaaatccagagcctcatccattgtaacatcacctcc
gtagtcaagatgacacagctaattctgaaacatatggaatcaaggcagaaaggtctcatc
ctgaacatttcttctgggatagccctgtttccttggcctctctactccatgtactcagct
tccaaggcgtttgtgtgcgcattttccaaggccctgcaagaggaatataaagcaaaagaa
gtcatcatccaggtgctgaccccatatgctgtctcgactgcaatgacaaagtatctaaat
acaaatgtgataaccaagactgctgatgagtttgtcaaagagtcattgaattatgtcaca
attggaggtgaaacctgtggctgccttgcccatgaaatcttggcgggctttctgagcctg
atcccggcctgggccttctacagcggtgccttccaaaggctgctcctgacacactatgtg
gcatacctgaagctcaacaccaaggtcaggtag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (2)   
   KEGG MODULE (2)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (16)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (7)   
   Pfam (7)   
All databases (81)   

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